Asclepiades of Myrlea was a Greek grammarian and historian who lived and worked in the 1st century BCE. He was born in Myrlea (later called Apamea) in the region of Bithynia, in what is now northwestern Turkey. He studied under the famous grammarian Apollodorus of Athens and later moved to Rome to teach. There, he was a contemporary of the Roman scholar Varro, placing him at the heart of intellectual life in the late Roman Republic.

His role was that of a scholar who specialized in grammar, history, and mythology. He wrote several treatises, but none of his works survive intact. They are known only through fragments and references by later ancient authors. His lost writings include a work On Grammar, a historical study On the History of Etruria, a History of Bithynia, and texts on mythology and specific grammatical topics.

According to modern scholars, Asclepiades was a significant figure in the transfer of Greek learning to Rome. His teachings are thought to have influenced Roman intellectuals like Varro, who helped systematize the study of the Latin language. Furthermore, his historical writings were used as sources by later geographers like Strabo, indicating his works were considered authoritative in antiquity. His career exemplifies the movement of Greek scholars to Rome, which played a key role in the development of Greco-Roman culture.