Euphro of Sicyon was a comic poet active in Greece during the 5th century BCE, the period known as Old Comedy. He was a citizen of Sicyon, a city in the northern Peloponnese. Very few facts about his life are known. According to later ancient sources, he wrote comedies, but the exact number is uncertain; one source claims he wrote seven plays, while only one title is confirmed from surviving evidence.

Only one of his works is known by name: a comedy called The Brothers. A single fragment from this play survives, quoted by the later writer Athenaeus. It features a character listing items for a dinner party, which is a typical example of the everyday humor found in Old Comedy. All his other works are lost, and their titles are not recorded.

Euphro is a minor but significant figure because he represents the geographic spread of comic playwriting beyond Athens in the Classical period. While Athens was the dominant center for comedy, poets from other cities like Sicyon also contributed to the genre. His surviving fragment is used by scholars as a small piece of evidence for the style and content of non-Athenian comedy and for insights into social customs of the time.