Evagrius of Epiphania was a Christian author from the 6th century CE, during the late antique period. He came from the city of Epiphania, modern Hama in Syria. He is known for writing a single major work, an Ecclesiastical History.

His history was written in two volumes and covered a long period, from around 385 CE to 593 or 594 CE. This work is now completely lost. All modern knowledge of it comes from a brief mention by a later historian, Evagrius Scholasticus, who used it as a source for his own history.

According to modern scholars, the significance of Evagrius of Epiphania lies entirely in this role as a source for later writers. His lost history provided material for the surviving work of Evagrius Scholasticus. He represents a common figure in late antique scholarship: a local historian whose work was absorbed into larger narratives but did not survive on its own. No other details of his life are known.